Diabetes Mellitus as a Determinant of Prognosis in Chronic Obstructive Pulmonary Disease: More than a Coincidence

Authors

  • Muhammad Umar Pulmonology Department, Lady Reading Hospital Peshawar

Keywords:

Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, Circulating Markers

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is among the most urgent public health issues of today. It is currently the third leading cause of death worldwide, taking the lives of more than 3 million people each year, and the incidence of COPD is rising, especially in low- and middle-income countries. In addition to its hallmark and characteristic of progressive airflow obstruction, COPD has long been recognized as involving systemic illness, marked by skeletal muscle impairment, weight loss, osteoporosis, cardiovascular disease, and systemic inflammation. Diabetes Mellitus (DM), especially type 2 DM, is yet another global epidemic, and currently affects more than 500 million people globally, with projections indicating an even sharper increase in incidence in the next two decades.

References

Ali B, Shah I, Ali A, Rehman E, Khan MK, Hakim H. Undiagnosed Chronic Obstructive Pulmonary Disease amongst Coronary Artery Disease Patients: A single centre study. Pak J Chest Med. 2022;28(4):414-9.

Mamillapalli C, Tentu R, Jain NK, Bhandari R. COPD and type 2 diabetes. Curr Respir Med Rev. 2019;15(2):112-9. DOI: 10.2174/1573398X15666190211155640.

Ho TW, Huang CT, Ruan SY, Tsai YJ, Lai F, Yu CJ. Diabetes mellitus in patients with chronic obstructive pulmonary disease — The impact on mortality. PLoS One. 2017;12(4):e0175794. DOI:10.1371/journal.pone.0175794.

Ali MO, Begum S, Begum N, Ali T, Ferdousi S, Begum A. FVC, FEV 1 and FEV 1/FVC% in Type 2 Diabetes and Their Relationships with Duration of the Disease. J Bangladesh Soc Physiol. 2009;4(2):81-7. DOI: 10.3329/jbsp.v4i2.4178.

Park SS, Perez JLP, Gandara BP, Agudelo CW, Ortega RR, Ahmed H, et al. Mechanisms linking COPD to type 1 and 2 diabetes mellitus: is there a relationship between diabetes and COPD?. Medicina. 2022;58(8):1030. DOI: 10.3390/medicina58081030.

Chen G, Sun J, Zheng J, Zhang X, Xie Y, Zhang Y. Elevated blood glucose is associated with severe exacerbation and death in COPD patients. Int J Chron Obstruct Pulmon Dis. 2022;17:423-431. DOI:10.2147/COPD.S378259.

Wang MT, Lai JH, Huang YL, Kuo FC, Wang YH, Tsai CL, et al. Use of antidiabetic medications and risk of COPD exacerbation requiring hospitalization: a disease risk score matched nested case–control study. Respir Res. 2020;21(1):319. DOI:10.1186/s12931-020-01547-1.

Anghel L, Popescu D, Mitache D, Coman I, Buga AM, Mitu F. Chronic obstructive pulmonary disease and type 2 diabetes mellitus: shared pathophysiological pathways, clinical implications and management strategies. J Clin Med. 2025;14(6):1809. DOI:10.3390/jcm14061809

Ahmed MM, Ghosh D, Malik FA, Javed H, Rafiq S, Ali M. Impact of diabetes mellitus on pulmonary functions in COPD. Q J Med. 2020;113(Suppl_1):hcaa043. DOI:10.1093/qjmed/hcaa043.

Downloads

Published

2025-06-02

How to Cite

Umar, M. (2025). Diabetes Mellitus as a Determinant of Prognosis in Chronic Obstructive Pulmonary Disease: More than a Coincidence. Pakistan Journal of Chest Medicine, 31(2), 89–92. Retrieved from https://www.pjcm.net/index.php/pjcm/article/view/1028

Issue

Section

Editorial

Most read articles by the same author(s)