Radiological manifestations of Granulomatosis with Polyangiitis

Abstract

Wegener's granulomatosis (Granulomatosis with Polyangiitis) is a small vessel vasculitis that can affect any organ system but mainly effects the respiratory tract and kidneys. It is diagnosed by a combination of clinical features, lab investigations, radiological findings and biopsy from a relevant organ. There is a strong association of Wegener's granulomatosis with C-ANCA levels ( cytoplasmic-antineutrophil cytoplasmic anyibodies). Early diagnosis is critical, as it gives the patient the best chance of remission with cytotoxix therapy. In this case series, the authors present six different radiological presentations of Granulomatosis with Polyangiitis, illustrating the need to include this disease in the differential diagnosis in such cases.