Circulatory and Adipose tissue Leptin and Adiponectin in relationship to resting energy expenditure in patients with Chronic Obstructive Pulmonary Disease
Keywords:
COPD, Resting Energy Expenditure, Adipokines, Leptin, Adiponectin, Metabolic AlterationsAbstract
Background: Chronic obstructive pulmonary disease (COPD) is a multifaceted respiratory disorder associated with systemic consequences, notably unintended weight loss. Objective: To examine the connections among circulatory and adipose tissue concentrations of leptin and adiponectin and resting energy expenditure (REE) in individuals diagnosed with COPD. Methodology: This study was carried out at the Department of Physiology, Swat Medical College, for a period of six months, from January 2021 to June 2021. The study involved a cohort of 70 individuals diagnosed with COPD. Subgroup analyses were conducted based on COPD severity. Participants were categorized into mild, moderate, and severe COPD subgroups. Resting energy expenditure (REE) was measured as a key parameter. The methodology included a detailed assessment of circulatory levels of leptin and adiponectin, exploring potential correlations with REE. Statistical analyses (SPSS) were applied to identify relationships between variables. Results: The circulatory levels of leptin were found to be 22.5 (SD 10.8), shedding light on the systemic presence of this adipokine. Additionally, adipose tissue biopsies revealed a mean leptin level of 18.7 (SD 9.5), emphasizing the local production within adipose depots. Correlation analyses showed a positive correlation between circulatory leptin and REE, indicating a potential stimulatory role of leptin in energy expenditure. Conversely, a negative correlation between circulatory adiponectin and REE suggested a potential role of adiponectin in metabolic processes related to energy expenditure. Multiple regression analysis further supported these findings, identifying circulatory leptin as a significant positive predictor of REE and circulatory adiponectin as a significant negative predictor. Conclusion: This research contributes valuable insights into the metabolic aspects of COPD, emphasizing the importance of addressing alterations in energy expenditure. Tailored interventions targeting specific COPD severity stages could enhance patient management.References
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