Examining the Impact of Pulmonary Embolism on Trauma and Orthopedic Patients: Incidence, Management, and Clinical Outcomes

Authors

  • Bahadar Ali Khan Department of Orthopedic and Trauma, Saidu Medical College, Swat - Pakistan
  • Asghar Khan Department of Orthopaedic, Saidu Teaching Hospital, Swat - Pakistan
  • Muhammad Saqib Department of Orthopedic, Gajju Khan Medical College, Bacha Khan Medical Complex, Swabi - Pakistan
  • Khadija Rehman Department of Surgery. Jinnah Postgraduate Medical Center, Karachi - Pakistan
  • Nasir Azim Department of Pulmonology, Fatima Jinnah Institutes of Chest Diseases, Quetta - Pakistan
  • Sohail Akhtar Bacha Khan Medical Complex, Swabi - Pakistan

DOI:

https://doi.org/10.1996/pjcm.v28i3.896

Keywords:

Trauma, Orthopedic Surgery, Pulmonary Embolism, Deep Venous Thrombosis

Abstract

Background: A frequent reason for mortality and severe disability is pulmonary embolism (PE). High death rates continue to be a prevalent issue even with advancements in diagnosis and treatment. Objective: The objective of the study was to explore the Incidence and outcome of pulmonary embolism in trauma and orthopaedic patients.Methodology: This retrospective study was conducted at the Department of Pulmonology and Orthopedic, Saidu Teaching Hospital, Swat from January 2017 to December 2019 after obtaining approval from the ethical committee of the institute. All the participants admitted for acute trauma or elective orthopaedic procedures during the study period were included. All the individuals with suspected PE were examined through (CT-PA) to conform PE, within 6 months following the operation or the injury. The study conducted a retrospective examination of case notes and computerized databases to determine the risk factors for venous thromboembolism (VTE), therapy type, thromboprophylaxis, and death of each patient.Results: Only 88 (0.48%) of the 18,153 patients hospitalized over the research period reported PE (positive CT-PA). Of these, 62 received acute trauma and 26 received elective surgery. Out of these approximately 75% of these individuals were given thromboprophylaxis. The three most often identified risk factors were being overweight, cardiovascular illness, and high blood pressure. After PE, the mortality rate was 0.07%. The death rate in the trauma group was 0.15 percent, whereas it was 0.02 percent for elective orthopaedic surgical procedures. The frequency of death was substantially correlated with the presence of at least two co-morbidities (unadjusted OR = 3.52, 95% confidence interval (CI) (1.34, 18.99), P = 0.034).Conclusion: The frequency of VTE was in parallel to previously reported results but there was a lower death rate. The treatment protocols were most effective performed in this study.

References

Markovic-Denic L, Zivkovic K, Lesic A, Bumbasirevic V, Dubljanin-Raspopovic ER, Bumbasirevic M. Risk factors and distribution of symptomatic venous thromboembolism in total hip and knee replacements: prospective study. Int Orthop. 2012;36:1299–1305.

Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Deslandes B, et al. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet. 2008;371:387-94.

Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, et al. Prevention of venous thromboembolism:the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.Chest. 2004;126:338S-400.

Linblad B, Sternby NH, Bergqvist D. Incidence of venous thromboembolism verified by necropsy over 30 years. BMJ. 1991;302:709-11.

Sandler DA, Martin JF:Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis? J R Soc Med. 1989;82:203-5.

Alikhan R, Peters F, Wilmott R, and Cohen AT. Fatal pulmonary embolism in hospitalized patients: a necropsy review. J Clin Pathol. 2004, 57:1254-7.

Prandoni P, Villalta S, Bagatella P, Rossi L, Marchiori A, Piccioli A, et al. The clinical course of deep-vein thrombosis. Prospective long-term follow-up of 528 symptomatic patients. Haematologica.1997; 82:423-8.

Pengo V, Lensing AW, Prins MH, Marchiori A, Davidson BL, Tiozzo F, et al. Thromboembolic Pulmonary Hypertension Study Group: Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med. 2004;350:2257-64.

Paffrath T, Wafaisade A, Lefering R, Simanski C, Bouillon B, Spanholtz T, et al. Trauma Registry of DGU:Venous thromboembolism after severe trauma: incidence, risk factors and outcome. Injury. 2010; 41:97-101.

Ho KM, Burrell M, Rao S, and Baker R. Incidence and risk factors for fatal pulmonary embolism after major trauma: a nested cohort study. Br J Anaesth.2010;105:596-602.

Poultsides LA, Gonzalez Della Valle A, Memtsoudis SG, Ma Y, Roberts T, Sharrock N, et al. Meta-analysis of cause of death following total joint replacement using different thrombo-prophylaxis regimens’ Bone Joint Surg Br. 2012;94:113–121.

Januel JM, Chen G, Ruffieux C, Quan H, Douketis JD, Crowther MA, et al. Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxisa systematic review. JAMA. 2012;307:294-303.

Subramaniam RM, Blair D, Gilbert K, Sleigh J, Karalus N. Computed tomography pulmonary angiogram diagnosis of pulmonary embolism. Australas Radiol. 2006;50:193-200.

Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, et al. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 2006, 354:2317-27.

Pruszczyk P, Torbicki A, Pacho R, Chlebus M, Kuch-Wocial A, Pruszynski B, et al. Noninvasive diagnosis of suspected severe pulmonary embolism: transesophageal echocardiography vs. spiral CT. Chest. 1997;112:722-8

NICE guidelines. Venous thromboembolism - reducing the risk (CG92). Available from URL: http://guidance.nice.org.uk/CG92.

Jiménez D, Aujesky D, Moores L, Gómez V, Lobo JL, Uresandi F, et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med. 2010;170:1383-9.

Cohen AT, Edmondson RA, Phillips MJ, Ward VP, Kakkar VV. The changing pattern of venous thromboembolic disease. Haemostasis.1996;26:65-71.

MacDonald D, Hobson S. VTE Prophylaxis for Elective Knee Replacement, e-Clinical VTE Guidelines Template. Leeds Teaching Hospitals Trust. Publication date: 1 July 2010.

MacDonald D, Hobson S: VTE Prophylaxis for Elective Hip Replacement, e-Clinical VTE Guidelines Template. Leeds Teaching Hospitals Trust. 2010.

Rao A, Monkhouse R, Gummerson N, Hobson S. VTE Prophylaxis for Hip Fracture, e Clinical VTE Guidelines Template. Leeds Teaching Hospitals Trust. 2010.

Rao A, Monkhouse R, Gummerson N, Hobson S. VTE Prophylaxis for Other Orthopedic Surgery, e-Clinical VTE Guidelines Template. Leeds Teaching Hospitals Trust. 2010.

Rao A, Monkhouse R, Gummerson N, Hobson S. VTE Prophylaxis for Lower Limb Plaster Casts, e-Clinical VTE Guidelines Template. Leeds Teaching Hospitals Trust. 2010.

Core Team R. A language and environment for statistical computing. Vienna, Austria: Foundation for Statistical Computing; 2013. Available from URL: http://www.R-project.org/.

Heit JA. The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol. 2008;28:370-2.

Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl OE, Schulman S,et al. Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th Ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.Chest. 2012;141(2 suppl):e278S–325.

Jawa RS, Warren K, Young D, Wagner M, Nelson L, Yetter D, et al. Venous thromboembolic disease in trauma and surveillance ultrasonography Surg Res. 2011;167:24–31.

Huseynova K, Xiong W, Ray JG, Ahmed N, Nathens AB. Venous thromboembolism as a marker of quality of care in trauma. J Am Coll Surg.2009;208:547–552.

Menaker J, Stein DM, Scalea TM. Incidence of early pulmonary embolism after injury. J Trauma.2007;63:620-4.

McNamara I, Sharma A, Prevost T, Parker M. Symptomatic venous thromboembolism following a hip fracture. Acta Orthop. 2009;80:687-92.

Estrada-Y-Martin RM, Oldham SA. CTPA as the gold standard for the diagnosis of pulmonary embolism. Int J Comput Assist Radiol Surg. 2011;6:557-63.

Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, et al. Multidetector CT for acute pulmonary embolism: embolic burden and clinical outcome. Chest. 2012;142(6):1417-24.

Pedersen AB, Sorensen HT, Mehnert F, Overgaard S, Johnsen SP. Risk factors for venous thromboembolism in patients undergoing total hip replacement and receiving routine thrombo-prophylaxis. J Bone Joint Surg Am. 2010;92:2156-64.

Pedersen AB, Mehnert F, Johnsen SP, Husted S, Sorensen HT. Venous thromboembolism in patients having knee replacement and receiving thrombo prophylaxis: a Danish population-based follow-up study. J Bone Joint Surg Am. 2011;93:1281-7.

Haut ER, Chang DC, Pierce CA, Colantuoni E, Efron DT, Haider AH, et al. Predictors of posttraumatic deep vein thrombosis(DVT): hospital practice versus patient factors - an analysis of the National Trauma Data Bank (NTDB). J Trauma.2009;66:994-1001.

Knudson MM, Ikossi DG, Khaw L, Morabito D, Speetzen LS. Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg. 2004;240:490-8.

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Published

2022-09-02

How to Cite

Khan, B. A. ., Khan, A., Saqib, M. ., Rehman, K. ., Azim, N. ., & Akhtar, S. . (2022). Examining the Impact of Pulmonary Embolism on Trauma and Orthopedic Patients: Incidence, Management, and Clinical Outcomes. Pakistan Journal of Chest Medicine, 28(3), 331–338. https://doi.org/10.1996/pjcm.v28i3.896

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