Exploring the Role of Vitamin D3 in Addressing Lung Dysfunction and Small Airways Degeneration in Chronic Obstructive Pulmonary Disease
Keywords:
Chronic Obstructive Pulmonary Disease, Vitamin D3, Dysfunctional Lung Anatomy, COPD SeverityAbstract
Background: Chronic Obstructive Pulmonary Disease (COPD) presents a significant global health challenge, necessitating comprehensive investigations into potential contributors and therapeutic avenues. Objectives: To investigate the intricate connections between dysfunctional lung anatomy, small airways degeneration, and the therapeutic potential of Vitamin D3 in COPD. Methodology: This prospective cross-sectional study was carried out at the Hayatabad Medical Complex in Peshawar, Pakistan, in the department of pulmonology. spanning January 2020 to February 2021. A total of 189 COPD participants aged 40 to 75 were enrolled in this study. Comprehensive data collection involved clinical observations, molecular analyses, and participant interviews. Statistical analyses, including regression, correlation assessments, and subgroup analyses, were conducted to explore the specified relationships. Results: Significant negative associations were found between dysfunctional lung anatomy, small airways degeneration, and Vitamin D3 levels. For dysfunctional lung anatomy, the beta coefficient (β) was -0.23 (p < 0.05), and for small airways degeneration, it was -0.18 (p < 0.05). Subgroup analyses highlighted lower Vitamin D3 levels in severe COPD (25.8 ng/mL, SD = 7.5) compared to moderate cases (30.5 ng/mL, SD = 8.2). Conclusion: The study underscores the complexity of pulmonary factors and Vitamin D3 in COPD, offering potential avenues for targeted interventions and therapeutic considerations. ÂReferences
Pauwels RA, Rabe KF. Burden and clinical features of chronic obstructive pulmonary disease (COPD). The Lancet. 2004;364(9434):613-20.
Martin C, Frija J, Burgel PR. Dysfunctional lung anatomy and small airways degeneration in COPD. Int J Chron Obstruct Pulmon Dis. 2013:7-13.
Higham A, Quinn AM, Cançado JE, Singh D. The pathology of small airways disease in COPD: historical aspects and future directions. Respir res. 2019;20(1):1-1.
Calderon J, Bellinger DC. Executive function deficits in congenital heart disease: why is intervention important? Cardio in the Young. 2015;25(7):1238-46.
Choi ME, Price DR, Ryter SW, Choi AM. Necroptosis: a crucial pathogenic mediator of human disease. JCI insight. 2019;4(15).
Higham A, Quinn AM, Cançado JE, Singh D. The pathology of small airways disease in COPD: historical aspects and future directions. Respir res. 2019;20(1):1-11.
Gea J, Casadevall C, Pascual S, Orozco-Levi M, Barreiro E. Respiratory diseases and muscle dysfunction. Expert Rev Respir Med. 2012;6(1):75-90.
Amann A, Smith D. Breath analysis for clinical diagnosis and therapeutic monitoring. 2005:201218.
Saleem A, Sharif S, Jarvis S, Madouros N, Koumadoraki E, Khan S. A comprehensive review on vitamin d as a novel therapeutic agent in chronic obstructive pulmonary disease. Cureus. 2021;13(2).
Riccioni G, D'orazio N, Menna V, De Lorenzo A. Fat soluble vitamins and immune system: an overview. Eur J Inflamm. 2003;1(2):59-64.
Pulvirenti G, Parisi GF, Manti S, Licari A, del Giudice MM, Salpietro C, et al. The immunomodulatory role of vitamin D in respiratory diseases. Curr Respir Med Rev. 2019;15(3):238-45.
Shukla SD, Vanka KS, Chavelier A, Shastri MD, Tambuwala MM, Bakshi HA, et al. Chronic respiratory diseases: An introduction and need for novel drug delivery approaches. In Targeting chronic inflammatory lung diseases using advanced drug delivery systems 2020:1-31. Academic Press.
Waatevik M, Skorge TD, Omenaas E, Bakke PS, Gulsvik A, Johannessen A. Increased prevalence of chronic obstructive pulmonary disease in a general population. Respir med. 2013;107(7):1037-45.
Afonso AS, Verhamme KM, Sturkenboom MC, Brusselle GG. COPD in the general population: prevalence, incidence and survival. Respir Med. 2011;105(12):1872-84.
Hanania NA, Sharma G, Sharafkhaneh A. COPD in the elderly patient. Semin Resp Crit Care. 2010.31 (05), 596-606).
McMillan Boyles C. An interpretive description of health equity in chronic obstructive pulmonary disease (COPD) clinical practice guidelines (Doctoral dissertation, Laurentian University of Sudbury).
Persson LJ, Aanerud M, Hiemstra PS, Hardie JA, Bakke PS, Eagan TM. Chronic obstructive pulmonary disease is associated with low levels of vitamin D. PloS One. 2012;7(6):e38934.
Janssens W, Decramer M, Mathieu C, Korf H. Vitamin D and chronic obstructive pulmonary disease: hype or reality? Lancet Respir Med. 2013;1(10):804-12.
Shaheen SO, Jameson KA, Robinson SM, Boucher BJ, Syddall HE, Sayer AA, Cooper C, Holloway JW, Dennison EM. Relationship of vitamin D status to adult lung function and COPD. Thorax. 2011: 20-10.
Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, et al. Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res. 2019;20(1):1-1.
Dougherty KA, Dilisio MF, Agrawal DK. Vitamin D and the immunomodulation of rotator cuff injury. J Inflamm Res. 2016 :123-31.
Kunisaki KM, Niewoehner DE, Connett JE; COPD Clinical Research Network. Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. Am J Respir Crit Care Med. 2012;185(3):286-90. PMC3297108.
Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, et al. High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2012;156(2):105-14.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Pakistan Journal of Chest Medicine
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
