Investigating the correlation between Pleural Effusion Volume and Diaphragmatic Function using Ultrasound Imaging

Authors

  • Aziz Ur Rehman Department of Radiology, Rawal Medical and Dental College, Islamabad - Pakistan
  • Shehla Aman Department of Anatomy, Gomal Medical College, Dera Ismail Khan – Pakistan
  • Mehrin Farooq Department of General Medicine, Lahore Medical and Dental College/Ghurki Trust Teaching Hospital, Lahore – Pakistan
  • Faiza Shafqat Department of Anatomy Combined Military Hospital, Lahore Medical College and Institute of Dentistry, Lahore - Pakistan
  • Syed Khurram Shehzad Kazmi Department of General Medicine, Lahore Medical and Dental College/Ghurki Trust Teaching Hospital, Lahore - Pakistan
  • Sobia Humerah Department of Physiology, Al Nafees Medical College and Hospital, Isra University, Islamabad - Pakistan

Keywords:

Pleural Effusion, Thoracic Ultrasound, Diaphragmatic Functions

Abstract

Background: The diaphragm is a necessary respiratory muscle, and its abnormal function may be caused by pleural effusion. Thoracic ultrasound is an accurate and simple method of investigating the relationship between diaphragmatic functions and pleural effusion.Objective: To determine the relationship between diaphragm functions and pleural effusion using ultrasound.Methodology: This study was a prospective case-control study conducted at the Department of Medicine, Lahore Medical and Dental College, Lahore, from January 2021 to December 2021. A total of 100 study cases were included in this study. For study purposes, these patients were divided into 2 groups, case (GI) and control (GII). Both groups comprise 50 study cases. The GI group comprised 50 patients with pleural effusion, whereas the GII group comprised 50 patients without pleural effusion. In both groups, diaphragmatic functions were also assessed through ultrasound.Results: Significant changes in diaphragm function, such as end-inspiratory thickness, fractional diaphragm thickening, and a shift in the amount of pleural effusion during deep breathing and quiet breathing, were observed during gastrointestinal thoracic ultrasound. When ultrasounds from the GI and GII groups were assessed, significant changes were observed in end-inspiratory thickness, end-expiratory thickness, fractional diaphragm thickening, excursion during quiet breathing, and deep breathing. The amount of pleural fluid is directly related to these changes.Conclusion: Thoracic ultrasonography has shown that various amounts of pleural effusion have a negative impact on diaphragmatic functioning.

References

Bhatnagar R, Maskell N. The modern diagnosis and management of pleural effusions. BMJ 2015; 351:h4520.

Liang XN, Lv CY, Shi HZ, Guo RJ, Li S. The role of ultrasound in determining the amount of pleural effusion. Ann Transl Med 2021; 9:972.

Amin MSA, Al-Asmar ABH, El-Naby HEDHA. Comparative study of different fourmulae of ultrasonographic quantificationof the amount of pleural effusion. Al-Azhar Med J 2021; 50:1459–1466.

Aldik MG, Sibly A, Telisinghe L, Daneshvar C. P235 assessment of diaphragm motion in patients with unilateral or asymmetrical pleural effusions. BMJ 2017; 72:A211.

Umbrello M, Mistraletti G, Galimberti A, Piva IR, Cozzi O, Formenti P. Drainage of pleural effusion improves diaphragmatic function in mechanically ventilated patients. Crit Care Resusc 2017; 19:64–70.

Ibitoye BO, Idowu BM, Ogunrombi AB, Afolabi BI. Ultrasonographic quantification of pleural effusion: comparison of four formulae.Ultrasonography 2018; 37:254–260.

Mayo P, Volpicelli G, Lerolle N, Schreiber A, Doelken P, Vieillard-Baron A. Ultrasonography evaluation during the weaning process: the heart, the diaphragm, the pleura and the lung. Intensive Care Med 2016; 42:1107–1117.

Petrof BJ, Jaber S, Matecki S. Ventilator-induced diaphragmatic dysfunction. Curr Opin Crit Care 2010; 16:19–25.

Lloyd T, Tang YM, Benson MD, King S. Diaphragmatic paralysis: the use of M mode ultrasound for diagnosis in adults. Spinal Cord 2006; 44:505–508.

Scillia P, Cappello M, Troyer AD. Determinants of diaphragm motion in unilateral diaphragmatic paralysis. J Appl Physiol 2004; 96:96–100.

Teichgräber UK, Hackbarth J. Sonographic bedside quantification of pleural effusion compared to computed tomography volumetry in ICU patients. Ultrasound Int Open 2018; 4:E131–E135.

Nagano A, Wakabayashi H, Maeda K, Kokura Y, Miyazaki S, Mori T, Fujiwara D. Respiratory sarcopenia and sarcopenic respiratory disability: concepts, diagnosis, and treatment. J Nutr Health Aging 2021; 25:507–515.

Kim TN, Choi KM. Sarcopenia: definition, epidemiology, and pathophysiology. J Bone Metab 2013; 20:1–10.

Cardenas LZ, Santana PV, Caruso P, Ribeiro de Carvalho CR, Pereira de Albuquerque AL. Diaphragmatic ultrasound correlates with inspiratory muscle strength and pulmonary function in healthy subjects. Ultrasound Med Biol 2018; 44:786–793.

LoMauro A, Aliverti A. Sex differences in respiratory function. Breathe (Sheff) 2018; 14:131–140.

Nucci RAB, de Souza RR, Suemoto CK, Busse AL, Maifrino LBM, Pasqualucci CA, Anaruma CA, Jacob-Filho W. Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: an autopsy study. Cell Physiol Biochem 2019; 53:648–655.

Ajime TT, Serre J, Wust RCI, Messa GAM, Poffe C, Swaminthan A, et al. Two weeks of smoking cessation reverse cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res 2021; 23:143–151.

Skaarup SH, Sara L, Federico Q, Alberto V, Paolo C, Glampietro M. Ultrasound evaluation of hemidiaphragm function following thoracentesis: a study on mechanisms of dyspnea related to pleural effusion. J Bronchol Interv Pulmonol 2020; 27:172–178.

Vignon P, Chastagner C, Berkane V, Chardac E, François B, Normand S, Bonnivard M, Clavel M, Pichon N, Preux PM, Maubon A. Quantitative assessment of pleural effusion in critically ill patients by means of ultrasonography. Critical care medicine. 2005 Aug 1;33(8):1757-63.

Leong JC, Lu WW, Luk KD, Karlberg EM. Kinematics of the chest cage and spine during breathing in healthy individuals and in patients with adolescent idiopathic scoliosis. Spine. 1999 Jul 1;24(13):1310.

Downloads

Published

2022-03-02

How to Cite

Rehman, A. U. ., Aman, S. ., Farooq, M. ., Shafqat, F. ., Kazmi, S. K. S. ., & Humerah, S. . (2022). Investigating the correlation between Pleural Effusion Volume and Diaphragmatic Function using Ultrasound Imaging. Pakistan Journal of Chest Medicine, 28(1), 80–86. Retrieved from http://www.pjcm.net/index.php/pjcm/article/view/834

Issue

Section

Original Article

Most read articles by the same author(s)