Serum Levels of Coenzyme Q10, Copper, Zinc, and Lipid Peroxidation, and the Antioxidant Potential of Zinc Picolinate in Chronic Obstructive Pulmonary Disease Patients

Authors

  • Syeda Masooma Hussain Department of Biochemistry, Rehman College of Dentistry, Peshawar - Pakistan
  • Farhat Rehman Department of Physiology, Bacha Khan Medical College (BKMC), Mardan - Pakistan
  • Rakhshanda Naheed Department of Physiology, Loralai Medical College, Loralai - Pakistan
  • Aneela Mehr Department of biochemistry, KMU-IMS, Kohat - Pakistan
  • Zara Khalid Khan Department of Biochemistry, Rawal Institute of Health Sciences (RIHS), Islamabad - Pakistan
  • Nadia Qazi Department of Community Medicine, Northwest School of Medicine, Peshawar - Pakistan

DOI:

https://doi.org/10.1996/pjcm.v28i2.850

Keywords:

COPD, Antioxidant, Coenzyme Q10, Copper

Abstract

Background: Chronic obstructive pulmonary disease, is often known as a serious global health issue that necessitates creative approaches to treat its complex pathogenesis. It is considered that trace components have a role in the development of many disorders, in both direct and indirect ways. Objective: This study investigates the effects of zinc picolinate consumption on lipid peroxidation, zinc, copper, and Coenzyme Q10 levels in individuals with COPD, while also exploring its antioxidant potential and implications for the management of the disease Methodology: In a study conducted between January 2021 and 2022, 71 participants were enrolled to investigate the impact of zinc picolinate supplements on oxidative stress indicators. Serum biomarkers including Coenzyme Q10, copper, zinc, and lipid peroxidation were assessed at baseline and study conclusion. Adverse events and participant compliance were documented. Subgroup analyses based on COPD severity were conducted, focusing on changes in serum markers. Paired t-tests indicated significance (p < 0.05) in changes before and after supplementation. Top of Form Results: The research included 71 people who had been diagnosed with chronic obstructive pulmonary disease. Following dietary supplements, there was a substantial rise in Coenzyme Q10 levels (p = 0.032) and a tendency towards significance in zinc levels (p = 0.078), reflecting a potential antioxidative impact. Adverse events related to zinc picolinate were minimal (7.04%), and compliance was high (92.5%). Conclusion: These findings contribute valuable insights to the literature on zinc's antioxidant properties in COPD, supporting further research to delineate its long-term effects and inform tailored therapeutic interventions.  

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Published

2022-06-02

How to Cite

Syeda Masooma Hussain, Farhat Rehman, Rakhshanda Naheed, Aneela Mehr, Zara Khalid Khan, & Nadia Qazi. (2022). Serum Levels of Coenzyme Q10, Copper, Zinc, and Lipid Peroxidation, and the Antioxidant Potential of Zinc Picolinate in Chronic Obstructive Pulmonary Disease Patients. Pakistan Journal of Chest Medicine, 28(2), 173–179. https://doi.org/10.1996/pjcm.v28i2.850

Issue

Vol. 28 No. 2 (2022)

Section

Original Article

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