Role of Supplementation of Vitamin C and D in their Low Serum Values in Critically Ill COPD Patients of Tertiary Care Hospital

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a global health concern necessitating comprehensive management strategies. Most research during the past two decades has shown that COPD risk is connected with antioxidant vitamins and anti-oxidant eating habits. Vitamin deficiency has been linked to lowered natural defences and an increased risk of airway inflammation.   Objective: The present study aimed to investigate the impact of vitamin C and D supplementation on critically ill COPD patients, specifically addressing associated nutritional deficiencies.   Methodology: This prospective cohort study, conducted at Hayatabad Medical Complex included a total of 150 critically ill COPD patients meeting specific inclusion criteria, including COPD diagnosis, a critical condition requiring hospitalization, and low serum levels of vitamin C and D, participating in the study. The intervention group received personalized vitamin C and D supplementation alongside standard COPD management, adhering to established dosage guidelines. Baseline assessments, intervention administration, and systematic evaluation of outcome measures, such as improving lung function and reducing COPD symptoms, were conducted.   Results: The intervention group demonstrated a significant increase in serum vitamin C (from 25.8 µg/dL to 32.1 µg/dL) and D levels (from 19.2 ng/mL to 28.4 ng/mL) after 8 weeks, contrasting with the control group. This nutritional intervention led to a noteworthy enhancement in forced expiratory volume in one second (FEV1), a reduction in COPD symptoms, and a decreased incidence of respiratory episodes. Conclusion: The findings suggest that targeted vitamin C and D supplementation, when integrated into standard COPD management, can effectively address nutritional deficiencies, resulting in improved lung function and reduced COPD symptoms in critically ill patients.