FREQUENCY OF RISK FACTORS FOR HEPATOTOXICITY IN PATIENTS WITH ANTITUBERCULOSIS DRUG INDUCED HEPATITIS

Abstract

OBJECTIVE: To determine the frequency of risk factors for hepatotoxicity inpatients presenting with anti- tuberculosis drugs induced hepatitisMETHODOLOGY: This descriptive cross sectional study included 73 admittedpatients taking anti tuberculous drugs and having clinical symptoms ofanorexia, nausea, vomiting and / or jaundice with raised liver functions tests.These patients were interviewed and further investigated to look for possiblerisk factors. Investigations apart from LFTs included complete blood picture,direct and indirect bilirubin, alkaline phosphatase, serum albumen, hemoglobin,Hepatitis B Antigen and Hepatitis C Antibodies.RESULTS: Of 73 patients 39 were females (53.40%) and 34 males (46.60%).Mean age was 50 years with 71% (52) patients older than 35 years. Mean BMI2 2 was 18.46 kg/m . 67% of the patients were under weight (BMI <18.5 kg/cm). Mean serum albumen was 2.86 gm/dl with 87.12% Patients having serum albumin level <3.5 gm/dl. 73% Patients were having hemoglobin < 10gm% with Mean hemoglobin of 10.25 gm%. 78.08% (57 patients) had pulmonary whereas 21.91% (16 patients) had extra pulmonary TB. 37 (64.9%) patients were sputum smear positive. Most patient (86.3%) patients had hepatotoxicity with in the intensive phase of therapy with mean of 3.92 weeks + 2.85 SD.CONCLUSION: ATT induced hepatotoxicity is significantly more frequent inpatients with risk factors and their early identification help in pointing outpatients prone to hepatotoxicity.